Now, we are familiar with how this plant has evolved throughout the ages alongside humankind, and has been integral to our lives from the beginning. But the fact is the plant material itself, while it is the ‘factory’ that generates all of the energy for cannabinoids, terpenes, terpenoids, flavonoids, enzymes and other beneficial chemicals to be created, contains nothing miraculous. It is the trichomes — the bulbous-headed stalks that cover the outside of the leaves and flowers of the plant, making it resemble a furry overcoat — or what most people refer erroneously to as “crystals” due to their shiny, sparkly appearance — are in fact, where ALL of the beneficial medicinal compounds in this marvelous plant are stored.

To date, there are over 100 cannabinoids (and counting) that all work in symbiosis in conjunction with a myriad of terpenes and other natural chemicals in Cannabis that can heal and restore our body’s natural endocannabinoid levels. These cannabinoids, in various ratios, along with terpenes, terpenoids, flavonoids and enzymes combine together to bring a homogeneous blend of relief to our bodies through ingestion.

The wide array of Cannabis strains throughout the years have evolved over eons of time, in a far-reaching and exotic mix of locations throughout the world, to produce one of the most diverse and varied set of phenotypes in a single plant genotype on the earth. We couldn’t have created a more complex mix of cannabinoid and terpene ratios throughout all of the land-race strains on Earth. And that does not even take into account all of the cross-breeding experiments performed by man over the past 200 years! There are over 480 chemical compounds in Cannabis, but our journey all begins with Cannabigerolic Acid (CBGA). Because of how important this cannabinoid is — we are going to dig DEEP into its origins.

Many phytocannabinoids have acidic precursors — these acidic precursors turn into cannabinoids through the process known as decarboxylation. CBGA is the precursor to the cannabinoid Cannabigerol (CBG). CBGA has been shown to be the first biogenic cannabinoid formed by the plant. It is affectionately known as the “stem cell” cannabinoid, given its ability to transform into other cannabinoids through decarboxylation and enzymatic reaction. CBG was discovered in 1964 by Gaoni and Mechoulam. Raphael Mechoulam is also accredited with being the first to give a complete explanation of the correct structure of Cannabidiol (CBD) in 1963, according to “Chemistry and Analysis of Phytocannabinoids and Other Cannabis Constituents” by Rudolf Brenneisen.

CBG is not psychoactive, although it is responsible for reducing intraoccqular pressure in the eye, which accounts for the heavy “weight-behind-the-eyes” feeling when ingested (which is sometimes misinterpreted as a psychoactive effect). It is formed through decarboxylation of CBGA. However, it is also the precursor for other acid precursors including THCA, CBDA, and CBCA. It is essential in the creation of common cannabinoids, including CBD and THC, as well as CBC.

There are currently two known types of Endocannabinoid receptors in our bodies, the CB1 and CB2 receptors. These are located throughout the body, but specifically concentrated in our brain and immune systems. Cannabinoids activate CB1 and CB2 receptors and change the way the body functions. The CB1 receptor is responsible for the psychoactive effects of THC and other cannabinoids, and CB1 receptor is located in central nervous system tissues, and also occur with less density in the lungs, liver and kidneys. The CB2 receptor is found in immune system cells. There is a widening belief that a third cannabinoid receptor exists in the blood vessels, lymph system and other cell types. 

All of this is diving fairly deep into the science and chemistry of Cannabis, but it is necessary to grasp the fundamental ways that Cannabis augments our body’s ability to monitor and balance our complex myriad of systems — and is integral in expanding our understanding and research into this amazing plant. The profound way in which cannabinoids, terpenes and the rest play an integral part into bringing our bodies into balance is just beginning to be understood enough to begin to test the efficacy of Cannabis-based whole- plant medicines. Furthermore, this “whole-plant” approach is not just endemic to Cannabis — we are finding a myriad of whole plant medicines that are derived from herbs and different flora that have existed and have been utilized throughout the centuries by mankind for treating illnesses. In fact, it is a foundation of cures for the different imbalances and ailments humans and animals have exhibited throughout history. However, we have never suffered so egregiously than in the past 150 years, as Cannabis, as well as other medicinal herbs and plants has been systematically stripped from our lives, as prescription “medicines” from the pharmaceutical industry pushes the home/homeopathic remedies grounded in our heritage out of existence.

The good news is, it is all coming back within our purview, as we have never needed healing, in such a fundamental and universal nature, as we do right now. These plants act almost as a panacea, curing all ailments our physical bodies suffer — because all we are doing is giving our bodies and minds the tools they need — the building blocks of proteins, fats, enzymes and such in the correct ratios, to enable our bodies to heal naturally.

Our intention for what we are currently involved in is to isolate and categorize specific strains of cannabis from our catalogue, that have specific cannabinoid and terpene ratio profiles, and match them to the specific ailments they treat best, given their chemical makeup. By doing this, rather than blending after-the-fact to create ratios of specific cannabinoids and terpenes, we can “blend” them in the genetics, so-to-speak, so that by just growing the strain out, processing and procuring its complete cannabinoid and terpene profile in the oil, we can then blend it to specific dosages in different delivery mediums to treat different specific ailments. While all cannabinoids are proving to be beneficial to our bodies, there are specific ratios, blends and dosages that provide optimum results when balanced to treat a specific issue or ailment. We have found amazing success in addition to whatever treatment the patient is already on, to supplement with a Cannabis treatment has proven to be of extreme benefit.

The delivery method is also extremely important to the treatment being applied. For instance, in the case of prostate cancer, we have prepared rectal syringes with a formulation in natural oils that afford maximum absorption and effectiveness with the least amount of discomfort. We have seen phenomenal results with these. For certain lung ailments, as well as anxiety, stress and other issues that need a quick, effective dose, vaporization is working extremely well, as the uptake of active ingredients by the lungs is almost instantaneously effective.

So,  as a jumping-off point, we started with these three cannabinoids (always balanced with the exact ratios of terpenes, terpenoids and flavonoids native to the specific strain) and their acid forms, as well, in varying amounts, to begin formulating medicines to address some specific health issues.

We began with a dosages of CBD suspended in a natural oil taken sublingually — and then went to a 1:1 CBD/THC blend, for treating other illnesses, and then to the acid forms of THC (not psychoactive) and CBD for additional benefits. We can deliver relief in many different ways, but currently, the main cannabinoid blends that we are creating that are actually being used in treatment are CBD, THC, THCA and, to a lesser extent, CBG. These are very simple medicines, as we are not ‘editing’ their chemical content in any way — we are using the whole-plant oils exactly as they are taken from the plant — and my gut feeling is that this is the key to the amazing healing properties, with an absolute minimum of side effects or discomfort.

We are currently participating in a very large-scale experiment to bring back these therapeutic Cannabis strains and couple them with emerging, novel and far more effective methods of delivery to bring the science of Cannabis Medicines out of the shadows and to the forefront. We are beginning with what we have currently worked on in order to bring it to the public: CBD as well as THC at different ratios in specific strains. We will be introducing these strains and new methods of treatment over the coming months…stay tuned.

We are grateful to the WeedWorld folks for assisting us with the task of communicating our findings as they emerge, so we can include the world in this research as it unfolds - it belongs to all of us. We are working to bring these strains to the masses, as well as processes of capturing whole-plant essences as completely as possible, using the simplest methods possible.

Finally, we want to share some of the unique delivery technologies we are pioneering, so that they can bring relief (TRUE relief) to the world.

by Fred DeLisio - published in Weed World issue 126